top of page

AGED Diagnostics

We are a team of geneticists and hepatologists who started our pursuits in 2018 when we realized the tools we were using in research were not being well translated into the clinic. We saw an opportunity to apply genomic innovation to improve the lives of patients. Our team is developing the most accurate blood test for liver disease (also known as nonalcoholic steatohepatitis or NASH).

Home: Welcome


While 1 in 3 Americans or 100 million people have liver disease, many are unaware until the disease has progressed to later stages at which point patient outcomes are poor and healthcare spending can cost up to $1,000,000 per patient. Conversely, early detection of liver disease is not only treatable, but fully reversible.

The sole diagnostic tool is a liver biopsy, which is expensive, invasive, prone to sampling error and bleeding. Imaging tools fail in nearly 60% of patients and there are zero accurate noninvasive tools. 

Embryonic Stem Cells
Home: Our Technology

Our Business

AGED Diagnostics is using genomic innovation to develop the most accurate blood test for liver disease to help physicians keep patients in the monitoring program, reduce the financial burden for health insurers and improve patient outcomes through early detection and intervention.

Petri Dish
Home: About Us


AGED tools can differentiate benign from advanced liver disease and simultaneously stage fibrosis (liver scarring). Our technology uses a targeted genomic sequencing assessment to measure the concentration of target biomarkers (genetic signatures) in circulation. The presence of biomarkers past a defined concentration indicates a diagnosis of liver disease (NASH) and/or fibrosis.

Home: About Us

Meet The Team


Rachel Zayas

Founder & CEO

Geneticist, MBA, Healthworx (CareFirst) Fellow, Halcyon Fellow

Topp Endicott_edited_edited_edited_edited_edited_edited_edited_edited.jpg

Dr. Justin Topp

Director of Scientific Innovation

Genomics Specialist Integrated DNA Technologies, Professor of Biotechnology


Dr. Bongsoo Park

Lead Bioinformaticist

Bioinformatics CRO, Researcher at NIH, Lecturer John Hopkins


Dr. Marius Bolni

Clinical Collaborator

Virologist and Professor of Medical Oncology at Mayo Clinic

Coleman Smith_edited_edited_edited_edited.jpg

Coleman Irving Smith, MD

Clinical Collaborator

Transplant Hepatologist, MedStar Georgetown University Hospital


Zayas R. Sison III A, Buetow K, Roberts LR, Kuhnsman A, Nagalo BM. Transcriptional Landscape of Hepatocellular Carcinoma Reveals that Patient Ethnic-Origin Influences Patterns of Expression.

Arora M, Bogenberger JM, Abdelrahman A, Leiting JL, Chen X, Egan JB, Kasimsetty A, Lenkiewicz E, Malasi S, Uson PLS, Nagalo BM, Zhou Y, Salomao MA, Kosiorek HE, Braggio E, Barrett MT, Truty MJ, Borad MJ. Evaluation of NUC-1031: a first-in-class ProTide in biliary tract cancer. Cancer Chemother Pharmacol. 2020 Jun;85(6):1063-1078. doi: 10.1007/s00280-020-04079-z. Epub 2020 May 21. PMID: 32440762.

Nagalo BM, Breton CA, Zhou Y, Arora M, Bogenberger JM, Barro O, Steele MB, Jenks NJ, Baker AT, Duda DG, Roberts LR, Russell SJ, Peng KW, Borad MJ. Oncolytic Virus with Attributes of Vesicular Stomatitis Virus and Measles Virus in Hepatobiliary and Pancreatic Cancers. Mol Ther Oncolytics. 2020 Sep 25;18:546-555. doi: 10.1016/j.omto.2020.08.007. Epub 2020 Aug 19. PMID: 32839735; PMCID: PMC7437509.

Yarmarkovich M, Farrel A, Sison III, A, di Marco, M, Raman P, Parris JL, Lee H, Stevanovich S, Maris JM. Immunogenicity and Immune Silence in Human Cancer (April 6, 2019). Cell Press. Available at SSRN: or

Eko Mba JM, Bisseye C, Ntsame Ndong JM, Mombo LE, Bengone C, Mouelet Migolet G, M'batchi B, Kosiorek HE, Butterfield RJ, Roberts LR, Borad MJ, Nagalo BM. Prevalent hepatitis B surface antigen among first-time blood donors in Gabon. PLoS One. 2018 Apr 13;13(4):e0194285. doi: 10.1371/journal.pone.0194285. PMID: 29652917; PMCID: PMC5898709.

Wongjarupong N, Yonli AT, Nagalo BM, Djigma FW, Somda SK, Hassan MA, Mohamed EA, Sorgho AP, Compaore TR, Soubeiga ST, Kiendrebeogo I, Sanou M, Diarra B, Yang HI, Chen CJ, Ouattara AK, Zohoncon TM, Martinson JJ, Buetow K, Chamcheu JC, Antwi SO, Borad MJ, Simpore J, Roberts LR. Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso. Hepatol Commun. 2020 Sep 15;4(12):1781-1792. doi: 10.1002/hep4.1595. PMID: 33305149; PMCID: PMC7706297.

Sorgho PA, Martinson JJ, Djigma FW, Yonli AT, Nagalo BM, Compaore TR, Obiri-Yeboah D, Diarra B, Sombie HK, Zongo AW, Ouattara AK, Soubeiga STR, Traore L, Roberts LR, Simpore J. Insights into the Interplay between KIR Gene Frequencies and Chronic HBV Infection in Burkina Faso. Mediterr J Hematol Infect Dis. 2018 Nov 1;10(1):e2018060. doi: 10.4084/MJHID.2018.060. PMID: 30416692; PMCID: PMC6223576.

Diarra B, Yonli AT, Sorgho PA, Compaore TR, Ouattara AK, Zongo WA, Tao I, Traore L, Soubeiga ST, Djigma FW, Obiri-Yeboah D, Nagalo BM, Pietra V, Sanogo R, Simpore J. Occult Hepatitis B Virus Infection and Associated Genotypes among HBsAg-negative Subjects in Burkina Faso. Mediterr J Hematol Infect Dis. 2018 Jan 1;10(1):e2018007. doi: 10.4084/MJHID.2018.007. PMID: 29326804; PMCID: PMC5760064.

Eko Mba JM, Bisseye C, Mombo LE, Ntsame Ndong JM, Mbina Ekayeng SC, Bengone C, M'batchi B, Nagalo BM. Assessment of rapid diagnostic tests and fourth-generation Enzyme-Linked Immunosorbent Assays in the screening of Human Immunodeficiency and Hepatitis B virus infections among first-time blood donors in Libreville (Gabon). J Clin Lab Anal. 2019 Mar;33(3):e22824. doi: 10.1002/jcla.22824. Epub 2018 Nov 28. PMID: 30485543; PMCID: PMC6818564.

Simpore A, Bisseye C, Nagalo BM, Sanou M, Nébié Y, Ghoma-Linguissi LS, Dahourou H, Sawadogo B, Djigma F, Ouattara S, Pietra V, Nichol J, Simpore J. Importance of extending the use of polymerase chain reaction in the diagnosis of venereal syphilis in a blood transfusion center in Burkina Faso, West Africa. Pan Afr Med J. 2014 May 15;18:56. doi: 10.11604/pamj.2014.18.56.3850. PMID: 26113890; PMCID: PMC4473781.

Zeba MT, Sanou M, Bisseye C, Kiba A, Nagalo BM, Djigma FW, Compaoré TR, Nebié YK, Kienou K, Sagna T, Pietra V, Moret R, Simporé J. Characterisation of hepatitis C virus genotype among blood donors at the regional blood transfusion centre of Ouagadougou, Burkina Faso. Blood Transfus. 2014 Jan;12 Suppl 1(Suppl 1):s54-7. doi: 10.2450/2013.0089-12. PMID: 24599906; PMCID: PMC3934227.

Tao I, Bisseye C, Nagalo BM, Sanou M, Kiba A, Surat G, Compaoré TR, Traoré L, Nikiema JB, Pietra V, Zongo JD, Simpore J. Screening of Hepatitis G and Epstein-Barr Viruses Among Voluntary non Remunerated Blood Donors (VNRBD) in Burkina Faso, West Africa. Mediterr J Hematol Infect Dis. 2013 Sep 2;5(1):e2013053. doi: 10.4084/MJHID.2013.053. PMID: 24106603; PMCID: PMC3787664.

Nagalo BM, Bisseye C, Sanou M, Kienou K, Nebié YK, Kiba A, Dahourou H, Ouattara S, Nikiema JB, Moret R, Zongo JD, Simpore J. Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa. Trop Med Int Health. 2012 Feb;17(2):247-53. doi: 10.1111/j.1365-3156.2011.02902.x. Epub 2011 Oct 12. PMID: 21988100.

Sombié HK, Sorgho AP, Kologo JK, Ouattara AK, Yaméogo S, Yonli AT, Djigma FW, Tchelougou D, Somda D, Kiendrébéogo IT, Bado P, Nagalo BM, Nagabila Y, Adoko ETHD, Zabsonré P, Millogo H, Simporé J. Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa). BMC Med Genet. 2020 Mar 19;21(1):55. doi: 10.1186/s12881-020-0990-9. PMID: 32188413; PMCID: PMC7081581.

Home: List

Get in Touch

3400 Prospect St, Washington DC 20007

Thanks for submitting!

bottom of page